Newly elected Governor Colin O'Connor struggles to bring balance to a shaken society. With the help of his childhood friend and android counterpart, The Supreme, he learns to navigate rocky waters invaded by the Humanizer party and Representative Joel Kennsington while his secret thirst for blood intensifies.

Across The River, his older sister, Celine balances the tumultuous success of her start-up biotech company, COLI*GO and her illicit affair with her chief of staff, Amanda MacDonald. Newly betrothed to old bloodline heir Martin Borges, Celine questions her desires for familial duty and independence.

Will Colin and Celine work together to restore the O'Connor family legacy or will their intensifying tensions push the siblings apart?